Purpose: The purpose of this study was to identify the relationship between spiritual well‐being (meaning/peace, and faith) and depression among Jordanian patients receiving hemodialysis. Methods: Cross‐sectional descriptive correlation design was used to carry out on a nationally representative convenience sample of 158 patients receiving hemodialysis at five different hospitals in Jordan. Results: The mean total score of the depression was 17.8 of the 40. While the mean total score of the spiritual well‐being was 36.9 of the 48. The Pearson's correlation coefficient test showed significant negative correlation between spiritual well‐being and depression (r = −.64, p < .005). Conclusion: Healthcare providers should consider spiritual well‐being in their assessment and interventions by helping the patients to establish meaning, peace, and faith to reduce patients' depression.