A triple component system which can serve basic communication and cognitive needs of developmentally disabled children in the Arab world is proposed. This system is based on a combinational cognitive model which merges Mayer’s Cognitive Theory of Multimedia Learning and Skinner’s Operant Conditioning Theory. The system aims to benefit three main groups of children: 1) children with hearing impairments (HI), 2) children with Autism Spectrum Disorder (ASD), and 3) children with Down syndrome (DS) and other intellectual disabilities (ID), in their struggle for augmentative communication and enhanced learning. This study elaborates on the cognitive models and the methodologies for each of the three proposed components: Pedagogical approach, Dynamic Arabic text translation to multimedia elements, Multimedia-based system for daily living task learning, as well as Cognitive multimedia tutorials and exercises. The proposed Multimedia-based triple component system has been tested on a group of 100 children, 50 with DS and 50 with other IDs. Evaluation results from these studies demonstrated that the multimedia system is effective in terms of cognition and motivation for children with DS and ID.